Isobel started her career in 2007, with a lead character in M.I. High, with Rachel Petladwala and Moustafa Chouein–Oglou. She starred in 23 episodes in M.I. High until 2008. She later appeared in other productions such as The Whistleblowers, The Bill, Little Dorrit, and did three episodes in Murderland on 2009.
Powley played as Maggie, in Tusk Tusk in London at the Royal Court Theatre in March 2009. In the middle of her theatre year, she was involved in a protest against university fee rises in 2010. Again, in 2011 she was on Broadway, as Thomasina in Arcadia at the Ethel Barrymore Theatre, also making her way at the Royal Court as Tilly in Jumpy. Continuing, the role in Jumpy, she transferred to West End at Duke of York’s Theatre in 2012.
Later that year, Bel Powley admitted to dating Douglas Booth, and plan to take their time learning each other’s ways and to commit to each other.