In September 2004, Ken got married to Dr. Tran Ho. Dr. Tran Ho is a family physician and she is popular for being a breast cancer survivor. As a married couple, they welcomed a twin daughter in 2008.
As a child, Ken joined Walter Hines Page High School. There he was active in several things. There he was the member of High IQ team and he also used to play violin in the orchestra. He completed his high school graduation at the age of 16 and for this he was honored with Greensboro's Youth of the Year award. He then joined Duke University and finally earned his M.D. in 1995 from University of North Carolina.
In 1995, Ken took part in Big Easy Laff-Off and at the end he also won this show. Then he began performing at the Improv and Laugh Factory comedy clubs as a comedian. Few months later, he moved to Los Angeles where he practiced medicine for several years. During that time, he also appeared in several shows. He finally made his acting debut in 1997 and that was in the television series, The Big Easy starring the role of Dr. Tang. For his role in The Hangover Part III, he earned the salary of $5,000,000. His net worth is said to be around $14 million.