Boscono spent her early life in Italy, later she moved to Kenya along with her family and started to live in a village between Malindi and Mombasa. She discovered her interest in modeling at the age of 17, after when her friend and mother inspired her. After her graduation, she made a contract with DNA Model Management, a modeling agency in New York City, where Matthew Gray Gubler, Shemar Moore, and Ian Somerhalder has also worked as a model.
After working with DNA Model Management, Boscono became favorite models of Karl Lagerfeld. Later, she appeared on the cover of Vogue for several times and performed in numerous ramp shows; soon she became an international model. Recently, she replaced Kate Moss and earned a named as a spokesperson for Hennes & Mauritz.
Boscono has appeared in numerous fashion shows and covers of magazines, including Blumarine, Chanel, Etro, Moschino, Yves Saint Laurent, Givenchy, Alessandro Dell'Acqua, Jean-Paul Gaultier, Escada, DKNY, Marc Jacobs. Likewise in Diesel Likewise in Alberta Ferretti, Roberto Cavalli, Dolce & Gabbana, Armani Exchange, NARS Cosmetics, Barneys New York, Hermes, H&M, John Galliano, Lanvin, Prada, Loewe, Pucci, Salvatore Ferragamo, and Missoni.
Boscono is an Italian by nationality and belongs to white ethnicity. She married her longtime boyfriend, Andreas Patti, after dating him for sometimes. However, the couple couldn't continue their married life and they divorced. She has blessed with a daughter Marialucas.
Boscono earns a huge amount of money from her professional modeling career. In 2005, she was listed on the World's 15 Top-Earning Supermodels by Forbes Magazines with the worth of $3,500,000. Her current net worth is estimated to be $12 million.