She acted in television commercials and the opera soap "As the World Turns" during her college days to earn extra money.She debuted in movies with George Cukor's Rich and Famous in 1981. She played a small role in 1986 blockbuster movie Top Gun which ultimately provided her a role in Steven Spielberg's Inner space in 1987 with a co-star Dennis Quaid, with whom she again acted in a remake of D.O.A. in 1988.
Meg Ryan got married to Denis Quaid in 1991. Her married life ended at an age of 40 when she divorced her husband, Denis Quaid, in 2001. She has two children with her ex-husband.
Meg Ryan holds an American nationality and belongs to white ethnicity. And she has a net worth of 45 Million Dollars.