Mo Collins is a married woman and she is married to her husband Alex Skuby in June 2013. Her husband Alex is a famous American actor, well known for playing the role of Doug Pruzan in the movie The King of Queens. The couple is together since their marriage but they do not have any children till now.
Mo Collins was diagnosed with a rare form of cancer known as gastrointestinal stromal tumor (GIST). She got to know about the disease after she noticed an odd lump in her abdomen. She also a primary tumor in her duodenum and was able to find a specialist doctor of her case and with the help of doctor, she was able to cure the disease.