In 1961, Nana got married to Yorgos Petsilas. Yorgos Petsilas is a guitarist of the trio "The Athenians". She also revealed that he is the first man whom she kissed for the first time in her life. As a married couple, she gave birth to two children together. Though she was happily married to him, this married life came to an end in 1975.
Few months later after Nana dissolved her first married life; she fell in love with André Chapelle. André Chapelle is her former sound technician. Though she began her romantic love affairs with him soon after her divorce, she didn't marry him till 2003. However, they got married on 13th of January 2003 and they are not a happily married couple.
Nana was raised along with her older sister Eugenía in Athens. Both of them have a lovely voice but because of their parent’s financial problem, her father promised to offer music lessons to only one. Though her older sister was better than her, she had remarkable singing voice. She began taking singing lessons since she was 12. In 1950, she joined Conservatoire. During her early musical career, she sang in several night clubs. Her debut album, Epitaphio was released in 1960. She had an outstanding year as a singer during 1960s and 1970s. She is one of the richest female singers with net worth of $280 Million.